Lexington, MA – Callahan Construction Managers announced it recently completed the multi-phase renovation for Revolution Labs in Lexington. The project features a 180,000sf core and shell research building that is occupied by anchor tenants Orum Therapeutics and Alchemab Therapeutics. The building is fully leased.
The facility was designed from the ground up to support both cutting-edge research and the lifestyle needs of today’s life sciences pioneers. Orum Therapeutics is a private, clinical-stage biotechnology company focused on the development of degrader-antibody conjugates (DACs) for cancer treatment, while Alchemab Therapeutics is developing solutions that utilize the immune system to create novel antibody therapies for challenging diseases.
Callahan was chosen to first oversee the core and shell of the laboratory facility, and then later retained to manage the fit-out of the interior office spaces. The occupied nature of the building during the second phase posed challenges that included lining the pipes of the structure’s sanitary system while the building was in use, requiring restricted water use and proactive planning with laboratory tenants.
Ongoing supply chain concerns made procurement of advanced laboratory components challenging, including specialty HVAC and electrical equipment. Callahan utilized the pre-construction phase to build a schedule that met critical deadlines while also taking into account what equipment needed to be ordered first to ensure occupancy goals were not impacted by unpredictable delivery dates.
“We are thrilled to see this new research facility come to life to support the groundbreaking efforts of the researchers that work here,” said Steve Callahan, Jr., vice president – business development, Callahan. “This project showcases the benefit of robust pre-construction planning, along with having a team that understands the specialized nature of lab construction. We wish Revolution Labs well as they utilize this space to its maximum potential.”
The building is on track to achieve WELL Certification.


